Article
Is there an association between uterine leiomyomas and acid phosphatase locus 1 polymorphism?
American journal of obstetrics and gynecology - 1 Jan 2009
Ammendola Maria Laura, Pietropolli Adalgisa, Lista Florigio, Saccucci Patrizia, Piccione Emilio, Bottini Egidio, Gloria-Bottini Fulvia
Abstract excerpt
OBJECTIVE: Platelet derived growth factor (PDGF) is involved in the development of leiomyomas. The low-molecular-weight phosphoprotein-tyrosine-phosphatase (LMWPTP), controlled by the highly polymorphic acid phosphatase locus 1 (ACP1), is able to dephosphorylate the PDGF receptor. Therefore, we searched for a possible association between ACP1 and leiomyomas. STUDY DESIGN: We studied 172 women hospitalized for...
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