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Article

The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection

26 Nov 2015

Abstract excerpt

RIG-I (Retinoic Acid Inducible Gene-I) is a cytosolic innate immune receptor that detects atypical features in viral RNAs as foreign to initiate a Type I interferon signaling response. RIG-I is present in an autoinhibited state in the cytoplasm and activated by blunt-ended double-stranded (ds)RNAs carrying a 5' triphosphate (ppp) moiety. These features found in many pathogenic RNAs are absent in cellular RNAs due...

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PMID: 26612866
DOI: 10.1093/nar/gkv1299

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