Article
Ketamine's antidepressant efficacy is extended for at least four weeks in subjects with a family history of an alcohol use disorder.
The international journal of neuropsychopharmacology - 31 Oct 2014
Niciu Mark J, Luckenbaugh David A, Ionescu Dawn F, Richards Erica M, Vande Voort Jennifer L, Ballard Elizabeth D, Brutsche Nancy E, Furey Maura L, Zarate Carlos A
Abstract excerpt
BACKGROUND: A single subanesthetic infusion of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has rapid and potent antidepressant properties in treatment-resistant major depressive disorder (TRD). As a family history of an alcohol use disorder is a positive predictor of ketamine's antidepressant response and the strength of the association increases over time, we hypothesized that depressed subjects...
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