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Article

Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist.

Biological psychiatry - 15 Jan 2009

Phelps Laura E, Brutsche Nancy, Moral Jazmin R, Luckenbaugh David A, Manji Husseini K, Zarate Carlos A

Abstract excerpt

BACKGROUND: A high rate of comorbidity exists between mood disorders and alcohol dependence. Furthermore, both ketamine, a dissociative anesthetic with a recently described rapid-onset antidepressant effect, and ethanol are N-methyl-D-aspartate (NMDA) receptor antagonists. Previous investigations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18996507
DOI: 10.1016/j.biopsych.2008.09.029
PMCID: PMC2727595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18996507-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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