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Article

Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release.

Cardiovascular research - 1 Apr 2015

Radwański Przemysław B, Brunello Lucia, Veeraraghavan Rengasayee, Ho Hsiang-Ting, Lou Qing, Makara Michael A, Belevych Andriy E, Anghelescu Mircea, Priori Silvia G, Volpe Pompeo, Hund Thomas J, Janssen Paul M L, Mohler Peter J, Bridge John H B, Poelzing Steven, Györke Sándor

Abstract excerpt

AIMS: Sudden death resulting from cardiac arrhythmias is the most common consequence of cardiac disease. Certain arrhythmias caused by abnormal impulse formation including catecholaminergic polymorphic ventricular tachycardia (CPVT) are associated with delayed afterdepolarizations resulting from diastolic Ca2+ release (DCR) from the sarcoplasmic reticulum (SR). Despite high response of CPVT to agents directly...

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Source

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Identifiers

PMID: 25538156
DOI: 10.1093/cvr/cvu262
PMCID: PMC4375407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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