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Molecular and Electrophysiological Bases of Catecholaminergic Polymorphic Ventricular Tachycardia

21 Feb 2007

Abstract excerpt

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disorder characterized by adrenergically mediated polymorphic ventricular tachyarrhythmias. Genetic investigations have identified two variants of the disease: an autosomal dominant form associated with mutations in the gene encoding the cardiac ryanodine receptor (RyR2) and a recessive form associated with homozygous...

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PMID: 17578347
DOI: 10.1111/j.1540-8167.2007.00766.x

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