Two-stage genome-wide search for epistasis with implementation to Recombinant Inbred Lines (RIL) populations.

Abstract excerpt

OBJECTIVE AND METHODS: This paper proposes an inegrative two-stage genome-wide search for pairwise epistasis on expression quantitative trait loci (eQTL). The traits are clustered into multi-trait complexes that account for correlations between them that may result from common epistasis effects. The search is done by first screening for epistatic regions and then using dense markers within the identified regions,...

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