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Article

On the Relationship Between High-Order Linkage Disequilibrium and Epistasis.

G3 (Bethesda, Md.) - 31 Jul 2018

Zan Yanjun, Forsberg Simon K G, Carlborg Örjan

Abstract excerpt

A plausible explanation for statistical epistasis revealed in genome wide association analyses is the presence of high order linkage disequilibrium (LD) between the genotyped markers tested for interactions and unobserved functional polymorphisms. Based on findings in experimental data, it has been suggested that high order LD might be a common explanation for statistical epistasis inferred between local...

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Identifiers

PMID: 29945968
DOI: 10.1534/g3.118.200513
PMCID: PMC6071592

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