Article
Dissecting genetic networks underlying complex phenotypes: the theoretical framework.
PloS one - 20 Jan 2011
Zhang Fan, Zhai Hu-Qu, Paterson Andrew H, Xu Jian-Long, Gao Yong-Ming, Zheng Tian-Qing, Wu Rong-Ling, Fu Bin-Ying, Ali Jauhar, Li Zhi-Kang
Abstract excerpt
Great progress has been made in genetic dissection of quantitative trait variation during the past two decades, but many studies still reveal only a small fraction of quantitative trait loci (QTLs), and epistasis remains elusive. We integrate contemporary knowledge of signal transduction pathways with principles of quantitative and population genetics to characterize genetic networks underlying complex traits,...
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