Article
Paclitaxel-induced neuropathy: potential association of MAPT and GSK3B genotypes.
BMC cancer - 22 Dec 2014
Park Susanna B, Kwok John B, Loy Clement T, Friedlander Michael L, Lin Cindy S-Y, Krishnan Arun V, Lewis Craig R, Kiernan Matthew C
Abstract excerpt
BACKGROUND: Paclitaxel treatment produces dose-limiting peripheral neurotoxicity, which adversely affects treatment and long-term outcomes. In the present study, the contribution of genetic polymorphisms to paclitaxel-induced neurotoxicity were assessed in 21 patients, focusing on polymorphisms involved in the tau-microtubule pathway, an important target of paclitaxel involved in neurotoxicity development....
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