Article
Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: a systematic review.
PloS one - 1 Jan 2015
Avalos Elisea, Catanzaro Donald, Catanzaro Antonino, Ganiats Theodore, Brodine Stephanie, Alcaraz John, Rodwell Timothy
Abstract excerpt
BACKGROUND: The detection of mutations in the gyrA and gyrB genes in the Mycobacterium tuberculosis genome that have been demonstrated to confer phenotypic resistance to fluoroquinolones is the most promising technology for rapid diagnosis of fluoroquinolone resistance. METHODS: In order to characterize the diversity and frequency of gyrA and gyrB mutations and to describe the global distribution of these...
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