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Article

Long-term persistence of functional thymic epithelial progenitor cells in vivo under conditions of low FOXN1 expression.

PloS one - 1 Jan 2014

Jin Xin, Nowell Craig S, Ulyanchenko Svetlana, Stenhouse Frances H, Blackburn C Clare

Abstract excerpt

Normal thymus function reflects interactions between developing T-cells and several thymic stroma cell types. Within the stroma, key functions reside in the distinct cortical and medullary thymic epithelial cell (TEC) types. It has been demonstrated that, during organogenesis, all TECs can be derived from a common thymic epithelial progenitor cell (TEPC). The properties of this common progenitor are thus of...

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Identifiers

PMID: 25531271
DOI: 10.1371/journal.pone.0114842
PMCID: PMC4273964

Genes

FOXN1
TEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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