Article
Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus.
PloS one - 1 Jan 2013
Bryson Jerrod L, Griffith Ann V, Hughes Bernard, Saito Fumi, Takahama Yousuke, Richie Ellen R, Manley Nancy R
Abstract excerpt
The thymus is composed of multiple stromal elements comprising specialized stromal microenvironments responsible for the development of self-tolerant and self-restricted T cells. Here, we investigated the ontogeny and maturation of the thymic vasculature. We show that endothelial cells initially enter the thymus at E13.5, with PDGFR-β(+) mesenchymal cells following at E14.5. Using an allelic series of the thymic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.