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Article

Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner.

Blood - 15 Jan 2009

Chen Lizhen, Xiao Shiyun, Manley Nancy R

Abstract excerpt

The postnatal thymus is the primary source of T cells in vertebrates, and many if not all stages of thymocyte development require interactions with thymic epithelial cells (TECs). The Foxn1 gene is a key regulator of TEC differentiation, and is required for multiple aspects of fetal TEC differentiation. Foxn1 is also expressed in the postnatal thymus, but its function after birth is unknown. We generated a Foxn1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18978204
DOI: 10.1182/blood-2008-05-156265
PMCID: PMC2628364

Genes

TEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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