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Article

Thymopoiesis in mice depends on a <i>Foxn1</i> -positive thymic epithelial cell lineage

9 Jul 2010

Abstract excerpt

The thymus is essential for T-cell development. Here, we focus on the role of the transcription factor Foxn1 in the development and function of thymic epithelial cells (TECs) of the mouse. TECs are of endodermal origin; they initially express Foxn1 and give rise to orthotopic (thoracic) and additional (cervical) thymi. Using Foxn1-directed cytoablation, we show that during embryogenesis, cervical thymi develop a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 20823228
DOI: 10.1073/pnas.1004623107

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Thymopoiesis in mice depends on a <i>Foxn1</i> -positive thymic epithelial cell lineagePMID 20823228Read ↗

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