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Article

Osteopontin expression in the brain triggers localized inflammation and cell death when immune cells are activated by pertussis toxin.

Mediators of inflammation - 1 Jan 2014

Marcondes Maria Cecilia Garibaldi, Ojakian Ryan, Bortell Nikki, Flynn Claudia, Conti Bruno, Fox Howard S

Abstract excerpt

Upregulation of osteopontin (OPN) is a characteristic of central nervous system pathologies. However, the role of OPN in inflammation is still controversial, since it can both prevent cell death and induce the migration of potentially damaging inflammatory cells. To understand the role of OPN in inflammation and cell survival, we expressed OPN, utilizing an adenoviral vector, in the caudoputamen of mice deficient...

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Identifiers

PMID: 25525298
DOI: 10.1155/2014/358218
PMCID: PMC4265371

Genes

CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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