Article
Genetic analysis of the influence of pertussis toxin on experimental allergic encephalomyelitis susceptibility: an environmental agent can override genetic checkpoints.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2000
Blankenhorn E P, Butterfield R J, Rigby R, Cort L, Giambrone D, McDermott P, McEntee K, Solowski N, Meeker N D, Zachary J F, Doerge R W, Teuscher C
Abstract excerpt
Pertussis toxin (PTX) is a potent ancillary adjuvant used to elicit several different autoimmune diseases, including experimental allergic encephalomyelitis (EAE). To delineate the genetics of PTX effect in EAE, we mapped EAE-modifying (eae-m) loci in cohorts of backcross mice immunized with and without PTX. In this study, we analyzed the genetic basis of EAE susceptibility and severity and the intermediate...
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