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Article

Evolutionarily emerged G tracts between the polypyrimidine tract and 3' AG are splicing silencers enriched in genes involved in cancer.

BMC genomics - 19 Dec 2014

Sohail Muhammad, Cao Wenguang, Mahmood Niaz, Myschyshyn Mike, Hong Say Pham, Xie Jiuyong

Abstract excerpt

BACKGROUND: The 3' splice site (SS) at the end of pre-mRNA introns has a consensus sequence (Y)nNYAG for constitutive splicing of mammalian genes. Deviation from this consensus could change or interrupt the usage of the splice site leading to alternative or aberrant splicing, which could affect n...

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Identifiers

PMID: 25523808
DOI: 10.1186/1471-2164-15-1143
PMCID: PMC4320613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25523808-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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