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Article

TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease.

Journal of neurochemistry - 1 Feb 2016

Gao Lei, Tian Mi, Zhao Hong-Yun, Xu Qian-Qian, Huang Yu-Ming, Si Qun-Cao, Tian Qing, Wu Qing-Ming, Hu Xia-Min, Sun Li-Bo, McClintock Shawn M, Zeng Yan

Abstract excerpt

We recently demonstrated that activation of tyrosine receptor kinase B (TrkB) by 7, 8-dihydroxyflavone (7, 8-DHF), the selective TrkB agonist, increased surface alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors (AMPARs) AMPA receptor subunit GluR1 (GluA1) subunit expression at the synapses of Fragile X Syndrome mutant mice. This present study investigated the effects of 7, 8-DHF on both...

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PMID: 26577931
DOI: 10.1111/jnc.13432

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