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Article

Interference of HCV replication by cell penetrable human monoclonal scFv specific to NS5B polymerase.

mAbs - 1 Jan 2014

Thueng-in Kanyarat, Thanongsaksrikul Jeeraphong, Jittavisutthikul Surasak, Seesuay Watee, Chulanetra Monrat, Sakolvaree Yuwaporn, Srimanote Potjanee, Chaicumpa Wanpen

Abstract excerpt

A new class of hepatitis C virus (HCV)-targeted therapeutics that is safe, broadly effective and can cope with virus mutations is needed. The HCV's NS5B is highly conserved and different from human protein, and thus it is an attractive target for anti-HCV therapeutics development. In this study, NS5B bound-phage clones selected from a human single chain variable antibody fragment (scFv) phage display library were...

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Identifiers

PMID: 25517317
DOI: 10.4161/mabs.29978
PMCID: PMC4622650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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