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Inhibition of Hepatitis C Virus Production by Aptamers against the Core Protein

5 Dec 2013

Abstract excerpt

Hepatitis C virus (HCV) core protein is essential for virus assembly. HCV core protein was expressed and purified. Aptamers against core protein were raised through the selective evolution of ligands by the exponential enrichment approach. Detection of HCV infection by core aptamers and the antiviral activities of aptamers were characterized. The mechanism of their anti-HCV activity was determined. The data...

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PMID: 24307579
DOI: 10.1128/jvi.03312-13

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