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Article

Single-domain intrabodies against hepatitis C virus core inhibit viral propagation and core-induced NFκB activation.

The Journal of general virology - 1 Apr 2016

Suzuki Ryosuke, Saito Kenji, Matsuda Mami, Sato Mitsuru, Kanegae Yumi, Shi Guoli, Watashi Koichi, Aizaki Hideki, Chiba Joe, Saito Izumu, Wakita Takaji, Suzuki Tetsuro

Abstract excerpt

Hepatitis C virus (HCV) core plays a key role in viral particle formation and is involved in viral pathogenesis. Here, constructs for single-domain intrabodies consisting of variable regions derived from mouse mAbs against HCV core were established. Expressed single-domain intrabodies were shown to bind to HCV core, and inhibit the growth of cell culture-produced HCV derived from JFH-1 (genotype 2a) and a TH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26861864
DOI: 10.1099/jgv.0.000423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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