Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mga is essential for the survival of pluripotent cells during peri-implantation development.

Development (Cambridge, England) - 1 Jan 2015

Washkowitz Andrew J, Schall Caroline, Zhang Kun, Wurst Wolfgang, Floss Thomas, Mager Jesse, Papaioannou Virginia E

Abstract excerpt

The maintenance and control of pluripotency is of great interest in stem cell biology. The dual specificity T-box/basic-helix-loop-helix-zipper transcription factor Mga is expressed in the pluripotent cells of the inner cell mass (ICM) and epiblast of the peri-implantation mouse embryo, but its function has not been investigated previously. Here, we use a loss-of-function allele and RNA knockdown to demonstrate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Embryo Implantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Gene Knockdown Techniques

Share to Gene Targeting

Share to Ornithine Decarboxylase

Share to Pluripotent Stem Cells

Share to Polyamines

Source

Open in PubMed Open full text

Identifiers

PMID: 25516968
DOI: 10.1242/dev.111104
PMCID: PMC4299147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mga is essential for the survival of pluripotent cells during peri-implantation development.PMID 25516968Read ↗

Postimplantation Mga expression and embryonic lethality of two gene-trap alleles.Semantic proximity Read ↗

N <sup>6</sup> -Methyladenosine Safeguards Mouse and Human Germline CompetenceSemantic proximity Read ↗

Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable.Semantic proximity Read ↗

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.Semantic proximity Read ↗

Developmental complexity of early mammalian pluripotent cell populations in vivo and in vitro.Semantic proximity Read ↗

Role of ornithine decarboxylase antizyme inhibitor in vivo.Semantic proximity Read ↗

TDG regulates cell cycle progression in human neural progenitorsSemantic proximity Read ↗

Dot1L methyltransferase activity is a barrier to acquisition of pluripotency but not transdifferentiationSemantic proximity Read ↗

Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells.Semantic proximity Read ↗

Male fetal germ cell differentiation involves complex repression of the regulatory network controlling pluripotencySemantic proximity Read ↗

Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos.Semantic proximity Read ↗

SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Interacting with Histone Citrullination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.