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Article

Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.

Alcoholism, clinical and experimental research - 1 Jan 2015

Blednov Yuri A, Benavidez Jillian M, Black Mendy, Ferguson Laura B, Schoenhard Grant L, Goate Alison M, Edenberg Howard J, Wetherill Leah, Hesselbrock Victor, Foroud Tatiana, Harris R Adron

Abstract excerpt

BACKGROUND: Peroxisome proliferator-activated receptor (PPAR) agonists reduce voluntary ethanol (EtOH) consumption in rat models and are promising therapeutics in the treatment for drug addictions. We studied the effects of different classes of PPAR agonists on chronic EtOH intake and preference in mice with a genetic predisposition for high alcohol consumption and then examined human genomewide association data...

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Source

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Identifiers

PMID: 25516156
DOI: 10.1111/acer.12610
PMCID: PMC4308472

Genes

PPARA
PPARD
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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