Article
Imputation accuracy is robust to cattle reference genome updates.
Animal genetics - 1 Feb 2015
Milanesi M, Vicario D, Stella A, Valentini A, Ajmone-Marsan P, Biffani S, Biscarini F, Jansen G, Nicolazzi E L
Abstract excerpt
Genotype imputation is routinely applied in a large number of cattle breeds. Imputation has become a need due to the large number of SNP arrays with variable density (currently, from 2900 to 777,962 SNPs). Although many authors have studied the effect of different statistical methods on imputation accuracy, the impact of a (likely) change in the reference genome assembly on imputation from lower to higher density...
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