Article
Investigating the accuracy of imputing autosomal variants in Nellore cattle using the ARS-UCD1.2 assembly of the bovine genome.
BMC genomics - 10 Nov 2020
Hermisdorff Isis da Costa, Costa Raphael Bermal, de Albuquerque Lucia Galvão, Pausch Hubert, Kadri Naveen Kumar
Abstract excerpt
BACKGROUND: Imputation accuracy among other things depends on the size of the reference panel, the marker's minor allele frequency (MAF), and the correct placement of single nucleotide polymorphism (SNP) on the reference genome assembly. Using high-density genotypes of 3938 Nellore cattle from Brazil, we investigated the accuracy of imputation from 50 K to 777 K SNP density using Minimac3, when map positions were...
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