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Article

Incidence and patterns of ALK FISH abnormalities seen in a large unselected series of lung carcinomas

1 Jan 2012

Abstract excerpt

BACKGROUND: Anaplastic lymphoma receptor tyrosine kinase (ALK) gene rearrangements have been reported in 2-13% of patients with non-small cell lung cancer (NSCLC). Patients with ALK rearrangements do not respond to EGFR-specific tyrosine kinase inhibitors (TKIs); however, they do benefit from small molecule inhibitors targeting ALK. RESULTS: In this study, fluorescence in situ hybridization (FISH) using a...

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PMID: 23198868
DOI: 10.1186/1755-8166-5-44

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