Article
A posttranscriptional mechanism that controls Ptbp1 abundance in the Xenopus epidermis.
Molecular and cellular biology - 1 Feb 2015
Méreau Agnès, Anquetil Vincent, Lerivray Hubert, Viet Justine, Schirmer Claire, Audic Yann, Legagneux Vincent, Hardy Serge, Paillard Luc
Abstract excerpt
The output of alternative splicing depends on the cooperative or antagonistic activities of several RNA-binding proteins (RBPs), like Ptbp1 and Esrp1 in Xenopus. Fine-tuning of the RBP abundance is therefore of prime importance to achieve tissue- or cell-specific splicing patterns. Here, we addressed the mechanisms leading to the high expression of the ptbp1 gene, which encodes Ptbp1, in Xenopus epidermis. Two...
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