Article
Epithelial Splicing Regulatory Protein 1 (ESRP1) is a new regulator of stomach smooth muscle development and plasticity.
Developmental biology - 15 Jun 2016
Sagnol Sébastien, Marchal Stéphane, Yang Yinshan, Allemand Frédéric, de Santa Barbara Pascal
Abstract excerpt
In vertebrates, stomach smooth muscle development is a complex process that involves the tight transcriptional or post-transcriptional regulation of different signalling pathways. Here, we identified the RNA-binding protein Epithelial Splicing Regulatory Protein 1 (ESRP1) as an early marker of developing and undifferentiated stomach mesenchyme. Using a gain-of-function approach, we found that in chicken embryos,...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Avian Proteins
- Cell Differentiation
- Cells, Cultured
- Chick Embryo
- DNA, Complementary
- Gene Expression Regulation, Developmental
- Gizzard, Avian
- Humans
- Mesoderm
- Models, Molecular