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Article

The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development.

Journal of cell science - 15 Sept 2017

Huang Huai-Wei, Zeng Xiaomei, Rhim Taiyoun, Ron David, Ryoo Hyung Don

Abstract excerpt

IRE1 mediates the unfolded protein response (UPR) in part by regulating XBP1 mRNA splicing in response to endoplasmic reticulum (ER) stress. In cultured metazoan cells, IRE1 also exhibits XBP1-independent biochemical activities. IRE1 and XBP1 are developmentally essential genes in Drosophila and mammals, but the source of the physiological ER stress and the relative contributions of XBP1 activation versus other...

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Identifiers

PMID: 28775151
DOI: 10.1242/jcs.203612
PMCID: PMC5612175

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development.PMID 28775151Read ↗

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