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Article

Evaluation of allele-specific PCR and immunohistochemistry for the detection of BRAF V600E mutations in hairy cell leukemia.

American journal of clinical pathology - 1 Jan 2015

Brown Noah A, Betz Bryan L, Weigelin Helmut C, Elenitoba-Johnson Kojo S J, Lim Megan S, Bailey Nathanael G

Abstract excerpt

OBJECTIVES: Detection of BRAF V600E mutations in hairy cell leukemia (HCL) has important diagnostic utility. In this study, we sought to compare immunohistochemistry with an antibody specific for this mutation to a sensitive molecular assay. METHODS: The performance of the BRAF V600E-specific VE1 antibody was compared with that of allele-specific polymerase chain reaction (PCR) in 22 formalin-fixed,...

Topics

Adult
Alleles
Biomarkers, Tumor
Female
Humans
Immunohistochemistry
Leukemia, Hairy Cell
Lymphoma, B-Cell
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 25511147
DOI: 10.1309/AJCPDN4Q1JTFGCFC

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25511147-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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