Article
Immunohistochemistry for BRAF V600E in the Differential Diagnosis of Hairy Cell Leukemia vs Other Splenic B-Cell Lymphomas.
American journal of clinical pathology - 1 Jul 2015
Turakhia Samir, Lanigan Christopher, Hamadeh Fatima, Swerdlow Steven H, Tubbs Raymond R, Cook James R
Abstract excerpt
OBJECTIVES: Recent reports have used immunohistochemistry (IHC) with a mutation-specific antibody to detect the BRAF V600E mutation, which is found in nearly all cases of hairy cell leukemia (HCL). To date, however, only a small number of non-HCL, splenic B-cell lymphomas have been examined by IH...
Topics
- Aged
- DNA Mutational Analysis
- Diagnosis, Differential
- Female
- Humans
- Immunohistochemistry
- Leukemia, Hairy Cell
- Lymphoma, B-Cell
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Proto-Oncogene Proteins B-raf