Article
The utility of BRAF V600E mutation-specific antibody VE1 for the diagnosis of hairy cell leukemia.
American journal of clinical pathology - 1 Jan 2015
Uppal Guldeep, Ly Vandi, Wang Zi-Xuan, Bajaj Renu, Solomides Charalambos C, Banks Peter M, Medeiros L Jeffrey, Peiper Stephen C, Gong Jerald Z
Abstract excerpt
OBJECTIVES: BRAF V600E mutation is characteristic of hairy cell leukemia (HCL). A V600E mutation-specific antibody, VE1, has been recently developed. We studied the diagnostic utility of this antibody in HCL and compared it with other B-cell neoplasms. METHODS: VE1 activity was assessed using immunohistochemistry in 90 mature B-cell neoplasms, including HCL (n = 17), HCL variant (n = 6), chronic lymphocytic...
Topics
- Antibodies, Monoclonal
- B-Lymphocytes
- Biomarkers, Tumor
- Biopsy
- Humans
- Immunohistochemistry
- Leukemia, Hairy Cell
- Mutation
- Proto-Oncogene Proteins B-raf