Article
Requisite analytic and diagnostic performance characteristics for the clinical detection of BRAF V600E in hairy cell leukemia: a comparison of 2 allele-specific PCR assays.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Sept 2015
Brown Noah A, Weigelin Helmut C, Bailey Nathanael, Laliberte Julie, Elenitoba-Johnson Kojo S J, Lim Megan S, Betz Bryan L
Abstract excerpt
Detection of high-frequency BRAF V600E mutations in hairy cell leukemia (HCL) has important diagnostic utility. However, the requisite analytic performance for a clinical assay to routinely detect BRAF V600E mutations in HCL has not been clearly defined. In this study, we sought to determine the level of analytic sensitivity needed for formalin-fixed, paraffin-embedded (FFPE) and frozen samples and to compare the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.