Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice.

PloS one - 1 Jan 2015

Szalai Gabor, Romero Roberto, Chaiworapongsa Tinnakorn, Xu Yi, Wang Bing, Ahn Hyunyoung, Xu Zhonghui, Chiang Po Jen, Sundell Birgitta, Wang Rona, Jiang Yang, Plazyo Olesya, Olive Mary, Tarca Adi L, Dong Zhong, Qureshi Faisal, Papp Zoltan, Hassan Sonia S, Hernandez-Andrade Edgar, Than Nandor Gabor

Abstract excerpt

OBJECTIVE: Most anti-angiogenic preeclampsia models in rodents utilized the overexpression of a truncated soluble fms-like tyrosine kinase-1 (sFlt-1) not expressed in any species. Other limitations of mouse preeclampsia models included stressful blood pressure measurements and the lack of postpartum monitoring. We aimed to 1) develop a mouse model of preeclampsia by administering the most abundant human placental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Gestational Age

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

Share to Placenta

Share to Pre-Eclampsia

Share to Protein Isoforms

Share to Ultrasonography

Share to Vascular Endothelial Growth Factor Receptor-1

Source

Open in PubMed Open full text

Identifiers

PMID: 25860260
DOI: 10.1371/journal.pone.0119547
PMCID: PMC4393117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice.PMID 25860260Read ↗

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic ActivitySemantic proximity Read ↗

Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosisSemantic proximity Read ↗

Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse ModelSemantic proximity Read ↗

Distinct phenotypes in the preeclamptic-like mouse model induced by adenovirus carrying sFlt1 and recombinant sFlt1 protein.Semantic proximity Read ↗

Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic MiceSemantic proximity Read ↗

Effect of Recombinant Placental Growth Factor 2 on Hypertension Induced by Full-Length Mouse Soluble fms-Like Tyrosine Kinase 1 Adenoviral Vector in Pregnant MiceSemantic proximity Read ↗

Current State of Preeclampsia Mouse Models: Approaches, Relevance, and StandardizationSemantic proximity Read ↗

Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse ModelSemantic proximity Read ↗

Long-term cardiovascular disorders in the STOX1 mouse model of preeclampsiaSemantic proximity Read ↗

A Recently Evolved Novel Trophoblast-Enriched Secreted Form of fms-Like Tyrosine Kinase-1 Variant Is Up-Regulated in Hypoxia and PreeclampsiaSemantic proximity Read ↗

Engineered trophoblast organoids recapitulate molecular and functional features of preeclampsiaSemantic proximity Read ↗

Renin-angiotensin system transgenic mouse model recapitulates pathophysiology similar to human preeclampsia with renal injury that may be mediated through VEGF.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.