Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preeclampsia is Associated With Reduced ISG15 Levels Impairing Extravillous Trophoblast Invasion

28 Jun 2022

Abstract excerpt

Among several interleukin (IL)-6 family members, only IL-6 and IL-11 require a gp130 protein homodimer for intracellular signaling due to lack of intracellular signaling domain in the IL-6 receptor (IL-6R) and IL-11R. We previously reported enhanced decidual IL-6 and IL-11 levels at the maternal-fetal interface with significantly higher peri-membranous IL-6 immunostaining in adjacent interstitial trophoblasts in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Pregnancy and preeclampsia studies
Share to Reproductive System and Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35837332
DOI: 10.3389/fcell.2022.898088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preeclampsia is Associated With Reduced ISG15 Levels Impairing Extravillous Trophoblast InvasionPMID 35837332Read ↗

Insufficient GDF15 expression predisposes women to unexplained recurrent pregnancy loss by impairing extravillous trophoblast invasionSemantic proximity Read ↗

GDF15 deficiency hinders human trophoblast invasion to mediate pregnancy loss through downregulating Smad1/5 phosphorylationSemantic proximity Read ↗

Genome-wide expression profile of first trimester villous and extravillous human trophoblast cellsSemantic proximity Read ↗

Interleukin (IL)11 mediates protein secretion and modification in human extravillous trophoblastsSemantic proximity Read ↗

Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin α5β1 Is a Modulator of Extravillous Trophoblast FunctionsSemantic proximity Read ↗

ITGB3 is reduced in pregnancies with preeclampsia and its influence on biological behavior of trophoblast cellsSemantic proximity Read ↗

miR-146b-5p downregulates IRAK1 and ADAM19 to suppress trophoblast proliferation, invasion, and migration in miscarriageSemantic proximity Read ↗

Human Trophoblast Differentiation Is Associated With Profound Gene Regulatory and Epigenetic ChangesSemantic proximity Read ↗

Sialic acid-binding immunoglobulin-like lectin-6 (SIGLEC6) is increased by hypoxia and inflammation; relevance to preeclampsiaSemantic proximity Read ↗

The pro-inflammatory cytokines IFN-α and TNF-α inhibit organoid-derived extravillous trophoblast invasionSemantic proximity Read ↗

Type I interferon alters invasive extravillous trophoblast functionSemantic proximity Read ↗

Concise Review: Growth Differentiation Factor 15 in Pathology: A Clinical Role?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.