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Interferon Stimulated Gene 15 Conjugates to Endometrial Cytosolic Proteins and Is Expressed at the Uterine-Placental Interface throughout Pregnancy in Sheep

5 Nov 2004

Abstract excerpt

Interferon-stimulated gene 15 (ISG15) is a ubiquitin homolog expressed in uteri of ruminants in response to interferon (IFN)-tau and is also induced during pregnancy in the uteri of mice, pigs, humans, and baboons. This study examined expression of ISG15 and its conjugation to target proteins in the ovine uterus beyond the period of IFNtau secretion by the conceptus. Although steady-state levels of ISG15 mRNA...

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Identifiers

PMID: 15528302
DOI: 10.1210/en.2004-1224

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Interferon Stimulated Gene 15 Conjugates to Endometrial Cytosolic Proteins and Is Expressed at the Uterine-Placental Interface throughout Pregnancy in SheepPMID 15528302Read ↗

Interferon-Stimulated Gene-15 (<i>Isg15</i>) Expression Is Up-Regulated in the Mouse Uterus in Response to the Implanting ConceptusSemantic proximity Read ↗

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Increased expression of interferon-stimulated gene 15 (ISG15) in cervical cells on day 14 of pregnancy in Holstein heifersSemantic proximity Read ↗

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Extracellular ISG15 triggers ISGylation via a type-I interferon independent non-canonical mechanism to regulate host response during virus infectionSemantic proximity Read ↗

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The Immune Environment in Human Endometrium during the Window of ImplantationSemantic proximity Read ↗

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