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Interferon-Stimulated Gene-15 (<i>Isg15</i>) Expression Is Up-Regulated in the Mouse Uterus in Response to the Implanting Conceptus

24 Mar 2003

Abstract excerpt

An early response of the human and bovine endometrium to pregnancy is induction of an interferon (IFN)-stimulated gene (ISG) that encodes the ubiquitin-related protein, ISG15. Because the mode of implantation differs among species, we tested whether Isg15 mRNA was also expressed in the mouse uterus in response to the implanting conceptus. Isg15 mRNA was detected in the mouse uterus and increased after d 4.5 of...

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PMID: 12810567
DOI: 10.1210/en.2002-0031

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