Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preimplantation maternal stress impairs embryo development by inducing oviductal apoptosis with activation of the Fas system.

Molecular human reproduction - 1 Nov 2016

Zheng Liang-Liang, Tan Xiu-Wen, Cui Xiang-Zhong, Yuan Hong-Jie, Li Hong, Jiao Guang-Zhong, Ji Chang-Li, Tan Jing-He

Abstract excerpt

STUDY QUESTION: What are the mechanisms by which the preimplantation restraint stress (PIRS) impairs embryo development and pregnancy outcome? SUMMARY ANSWER: PIRS impairs embryo development by triggering apoptosis in mouse oviducts and embryos,and this involves activation of the Fas system. WHAT IS KNOWN ALREADY: Although it is known that the early stages of pregnancy are more vulnerable than later stages to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blastocyst
Share to Corticotropin-Releasing Hormone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fas Ligand Protein

Share to fas Receptor

Share to Glucocorticoids

Share to Pregnancy, Animal

Share to Receptors, Corticotropin-Releasing Hormone

Share to Restraint, Physical

Source

Identifiers

PMID: 27475493
DOI: 10.1093/molehr/gaw052

Genes

CRH
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preimplantation maternal stress impairs embryo development by inducing oviductal apoptosis with activation of the Fas system.PMID 27475493Read ↗

Corticotrophin-releasing hormone and corticosterone impair development of preimplantation embryos by inducing oviductal cell apoptosis via activating the Fas system: an in vitro study.Semantic proximity Read ↗

Molecular mechanisms of early life stress—Lessons from mouse modelsSemantic proximity Read ↗

Chronic restraint stress induces excessive activation of primordial follicles in mice ovariesSemantic proximity Read ↗

Review of psychological stress on oocyte and early embryonic development in female miceSemantic proximity Read ↗

Embryo responses to stress induced by assisted reproductive technologiesSemantic proximity Read ↗

Periconception onset diabetes is associated with embryopathy and fetal growth retardation, reproductive tract hyperglycosylation and impaired immune adaptation to pregnancySemantic proximity Read ↗

The maternal-placental-fetal interface: Adaptations of the HPA axis and immune mediators following maternal stress and prenatal alcohol exposureSemantic proximity Read ↗

Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspringSemantic proximity Read ↗

Inflammatory signalling during the perinatal period: Implications for short- and long-term disease riskSemantic proximity Read ↗

Parental life events cause behavioral difference among offspring: Adult pre-gestational restraint stress reduces anxiety across generations.Semantic proximity Read ↗

mRNA and microRNA Profiles in the Amygdala Are Relevant to Susceptibility and Resilience to Psychological Stress Induced in Mice.Semantic proximity Read ↗

Chronic unpredictable mild stress-induced mouse ovarian insufficiency by interrupting lipid homeostasis in the ovarySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.