Article
Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs.
Circulation. Arrhythmia and electrophysiology - 1 Feb 2015
Chen Gaopeng, Li Sen, Karakikes Ioannis, Ren Lihuan, Chow Maggie Zi-Ying, Chopra Anant, Keung Wendy, Yan Bin, Chan Camie W Y, Costa Kevin D, Kong Chi-Wing, Hajjar Roger J, Chen Christopher S, Li Ronald A
Abstract excerpt
BACKGROUND: Human (h) embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) serve as a potential unlimited ex vivo source of cardiomyocytes (CMs). However, a well-accepted roadblock has been their immature phenotype. hESC/iPSC-derived ventricular (v) CMs and their engineered cardiac microtissues (hvCMTs) similarly displayed positive chronotropic but null inotropic responses to β-adrenergic...
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