Article
Generation of human induced pluripotent stem cell (iPSC) lines derived from five patients carrying the pathogenic phospholamban-R14del (PLN-R14del) variant and three non-carrier family members.
Stem cell research - 1 Apr 2022
Mittal Nishka, Dave Jaydev, Harakalova Magdalena, van Tintelen J Peter, Asselbergs Folkert W, Doevendans Pieter A, Costa Kevin D, Turnbull Irene C, Stillitano Francesca
Abstract excerpt
The R14del pathogenic variant in the phospholamban (PLN) gene (PLN-R14del), has been identified in families with hereditary cardiomyopathy, including dilated and arrhythmogenic cardiomyopathies. Here we have generated human iPSC lines from five PLN-R14del carriers and three non-carrier family members. Peripheral blood mononuclear cells (PBMC) were obtained from the eight individuals and reprogrammed using Sendai...
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