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Article

Generation of two induced pluripotent stem cell lines carrying the phospholamban R14del mutation for modeling ARVD/C.

Stem cell research - 1 Aug 2022

Vera Carlos D, Manhas Amit, Shenoy Sushma P, Wheeler Matthew T, Sallam Karim, Wu Joseph C

Abstract excerpt

The phospholamban (PLN) R14del mutation is associated with arrhythmogenic right ventricular dysplasia (ARVD/C). ARVD/C is a cardiac disease characterized by arrhythmias and structural abnormalities in the right ventricle. Because PLN is a regulator of calcium release, this mutation can have deleterious effects on tissue integrity and contraction. This mutation is a trinucleotide (AGA) deletion that leads to an...

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Identifiers

PMID: 35700631
DOI: 10.1016/j.scr.2022.102834
PMCID: PMC9476586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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