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Article

Promoting Autophagy Mitigates Stress-Induced Remodeling in Patient iPSC-CMs with the Phospholamban R9C Mutation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Feb 2026

Yu Qi, Shen Yawei, Barndt Robert J, Sallam Karim, Tang Ying, Brown Cameron E, Li Xiao, Chan Stephen Y, Wu Joseph C, Liu Qing, Wu Haodi

Abstract excerpt

Phospholamban (PLN) is a key regulator of adrenergic signaling and calcium homeostasis in cardiomyocytes. The PLN R9C mutation causes early-onset dilated cardiomyopathy (DCM) and premature death, yet the mechanisms underlying its pathogenic remodeling remain unclear. In this study, patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) harboring the PLN R9C and their isogenic corrected...

Topics

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Myocytes, Cardiac
Autophagy
Calcium
Calcium-Binding Proteins
Cardiomyopathy, Dilated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Induced Pluripotent Stem Cells

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Identifiers

PMID: 41309526
DOI: 10.1002/advs.202511480
PMCID: PMC12866708

Genes

PLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Promoting Autophagy Mitigates Stress-Induced Remodeling in Patient iPSC-CMs with the Phospholamban R9C Mutation.PMID 41309526Read ↗

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