Article
Mendelian randomization analysis indicates serum urate has a causal effect on renal function in Chinese women.
International urology and nephrology - 1 Nov 2017
Liu Jing, Zhang Hui, Dong Zheng, Zhou Jingru, Ma Yanyun, Li Yuan, Qian Qiaoxia, Yuan Ziyu, Zhang Juan, Yang Yajun, Wang Xiaofeng, Chen Xingdong, Zou Hejian, Jin Li, Wang Jiucun
Abstract excerpt
PURPOSE: High levels of serum uric acid can predict the progression of stage I and II chronic kidney disease (CKD), but whether serum urate is an independent risk factor or has causal impact on serum creatinine (SCr) and renal function remains unclear. METHODS: Mendelian randomization was used to determine whether serum uric acid had a causal effect on renal function, represented by estimated glomerular...
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