Article
Association of the clock genes polymorphisms with colorectal cancer susceptibility.
Journal of surgical oncology - 1 Dec 2013
Karantanos Theodoros, Theodoropoulos George, Gazouli Maria, Vaiopoulou Anna, Karantanou Christina, Stravopodis Dimitrios J, Bramis Konstantinos, Lymperi Maria, Pektasidis Dimitrios
Abstract excerpt
BACKGROUND AND OBJECTIVES: The circadian rhythm regulates the cell cycle progression and DNA damage response. The aim of our study was to investigate the association between polymorphisms in the CLOCK1, PER2, and PER3 genes with the colorectal cancer (CRC) susceptibility and clinicopathological variables. METHODS: Four hundred two CRC patients and 480 healthy controls were included in a case-control study....
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