A polymorphism in interferon L3 is an independent risk factor for development of hepatocellular carcinoma after treatment of hepatitis C virus infection.

doi:10.1016/j.cgh.2014.10.035

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Article

A polymorphism in interferon L3 is an independent risk factor for development of hepatocellular carcinoma after treatment of hepatitis C virus infection.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 May 2015

Chang Kuo-Chin, Tseng Po-Lin, Wu Yi-Ying, Hung Hung-Chao, Huang Chao-Min, Lu Sheng-Nan, Wang Jing-Houng, Lee Chuan-Mo, Chen Chien-Hung, Tsai Ming-Chao, Yen Yi-Hao, Lin Ming-Tsung, Wu Cheng-Kun, Huang Chao-Cheng, Chen Hsiu-Hsi, Hu Tsung-Hui

Abstract excerpt

BACKGROUND & AIMS: Polymorphisms in interferon (IFN)L3 (encodes IFNλ3 or interleukin 28B) are associated with outcomes of treatment for hepatitis C virus (HCV) infection. However, there is controversy regarding how polymorphisms in IFNL3 affect the risk for development of hepatocellular carcinoma (HCC) in patients treated with pegylated interferon and ribavirin. METHODS: In a retrospective study, we analyzed data...

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PMID: 25460552
DOI: 10.1016/j.cgh.2014.10.035

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IFNL3
AFP

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