Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity.

Neuro-degenerative diseases - 1 Jan 2015

Batelli Sara, Invernizzi Roberto William, Negro Alessandro, Calcagno Eleonora, Rodilossi Serena, Forloni Gianluigi, Albani Diego

Abstract excerpt

BACKGROUND: Dopaminergic degeneration is a major finding in brains of patients with Parkinson's disease (PD), together with Lewy bodies, intraneuronal inclusions mainly composed of the fibrillogenic protein α-synuclein (α-syn). The familial-PD-related protein DJ-1 was reported to reduce dopaminergic degeneration triggered by α-syn or by the dopaminergic-selective neurotoxin 6-hydroxydopamine (6-OHDA). OBJECTIVE:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesencephalon

Share to Nerve Degeneration

Share to Oncogene Proteins

Share to Oxidopamine

Share to Peroxiredoxins

Share to Protein Deglycase DJ-1

Source

Identifiers

PMID: 25500798
DOI: 10.1159/000367993

Genes

TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity.PMID 25500798Read ↗

In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategiesSemantic proximity Read ↗

Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70.Semantic proximity Read ↗

Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein.Semantic proximity Read ↗

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.Semantic proximity Read ↗

How can <scp>rAAV</scp>‐α‐synuclein and the fibril α‐synuclein models advance our understanding of Parkinson's disease?Semantic proximity Read ↗

Transduced Tat-DJ-1 Protein Protects against Oxidative Stress-Induced SH-SY5Y Cell Death and Parkinson Disease in a Mouse ModelSemantic proximity Read ↗

Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease.Semantic proximity Read ↗

Viral Vector Mediated Overexpression of Human α-Synuclein in the Nigrostriatal Dopaminergic Neurons: A New Model for Parkinson's DiseaseSemantic proximity Read ↗

Cellular models of alpha‐synuclein toxicity and aggregationSemantic proximity Read ↗

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons.Semantic proximity Read ↗

Transduced Tat-alpha-synuclein protects against oxidative stress in vitro and in vivo.Semantic proximity Read ↗

Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.