Article
Lack of intracellular trehalose affects formation of Escherichia coli persister cells.
Microbiology (Reading, England) - 1 Apr 2015
Kuczyńska-Wiśnik Dorota, Stojowska Karolina, Matuszewska Ewelina, Leszczyńska Daria, Algara María Moruno, Augustynowicz Mateusz, Laskowska Ewa
Abstract excerpt
Persisters are dormant antibiotic-tolerant cells that usually compose a small fraction of bacterial populations. In this work, we focused on the role of trehalose in persister formation. We found that the ΔotsA mutant, which is unable to synthesize trehalose, produced increased levels of persisters in the early stationary phase and under heat stress conditions. The lack of trehalose in the ΔotsA mutant resulted...
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