Article
The formation of persister cells in stationary-phase cultures of Escherichia coli is associated with the aggregation of endogenous proteins.
PloS one - 1 Jan 2013
Leszczynska Daria, Matuszewska Ewelina, Kuczynska-Wisnik Dorota, Furmanek-Blaszk Beata, Laskowska Ewa
Abstract excerpt
Persister cells (persisters) are transiently tolerant to antibiotics and usually constitute a small part of bacterial populations. Persisters remain dormant but are able to re-grow after antibiotic treatment. In this study we found that the frequency of persisters correlated to the level of protein aggregates accumulated in E. coli stationary-phase cultures. When 3-(N-morpholino) propanesulfonic acid or an...
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