Host Cell Oxidative Stress Induces Dormant Staphylococcus aureus Persisters.

doi:10.1128/spectrum.02313-21

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Article

Host Cell Oxidative Stress Induces Dormant Staphylococcus aureus Persisters.

Microbiology spectrum - 23 Feb 2022

Peyrusson Frédéric, Nguyen Tiep Khac, Najdovski Tome, Van Bambeke Françoise

Abstract excerpt

Persisters are transiently nongrowing and antibiotic-tolerant phenotypic variants identified in major human pathogens, including intracellular Staphylococcus aureus. Due to their capacity to regrow once the environmental stress is relieved and to promote resistance, persisters possibly contribute to therapeutic failures. While persistence and its related quiescence have been mostly studied under starvation,...

Topics

Adenosine Triphosphate
Anti-Bacterial Agents
Energy Metabolism
Humans
Microbial Viability
Oxidative Stress
Phenotype
Reactive Oxygen Species
Staphylococcal Infections
Staphylococcus aureus

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Identifiers

PMID: 35196815
DOI: 10.1128/spectrum.02313-21
PMCID: PMC8865412

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